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CRISPR crunch

Genetic engineering CRISPR crunch A row over who invented a new gene-editing technique heats up Feb 20th 2016  |  WASHINGTON, DC  |...

sábado, 25 de junho de 2016

How to Know If You Need to Patent Your Product

Q: I'm ready to step out of my basement workshop and introduce my invention to the world. Do I really need to get a patent first?
A: You've designed a better mousetrap. And you're anxious to get the production and sales processes snapping so you can sooner start counting your profits. Not so fast. You might first want to think about applying for a patent.
Harris A. Wolin, an intellectual property attorney in Morristown, N.J., who has filed patent applications for products ranging from dog toys to lasers, says it's essential for entrepreneurs to consider whether their new product requires a patent to help make it commercially viable. "I've been doing this long enough to know that if you don't have a business discussion, then there's a disconnect," Wolin says.
In legal parlance, a patent is what's known as a negative right. Wolin explains that by granting your patent, the U.S. government endows you with the exclusive right to exclude others from making, using or selling your work. It's a form of protection that enables you to enter your product or idea into the marketplace with some assurance (though no guarantee) that another entrepreneur won't try to claim it as his or her own.
"If you're in a crowded field, the ability to get meaningful protection might be slim," Wolin says. "If you have a breakthrough invention without historical precedent, your ability to get broader patent protection is much greater."
Patents issued by the U.S. Patent and Trademark Office are enforceable only within the States, which means they also cover goods being imported into the country. That's a key distinction, because foreign countries with weak patent laws routinely inundate the market with knockoff products.
"The only way you're going to control your product in the market is if you have the ability to tell others to stop," Wolin says. "In the United States and elsewhere, it's the patent system. That's the only way."
There are three types of patents: utility (which covers function), design (which covers aesthetics) and plant (which covers, well, plants--of the botanical variety). That better mousetrap, for example, would require a utility patent. Wolin says the average utility patent application costs $5,000 to $10,000 to prepare, but that figure can go much higher depending on the technological complexity of the concept. A 100-page application that requires, say, 50 drawings could easily cost more than $10,000.
Once an application is filed--at which point your product is considered "patent pending"--the patent office might contest some of your claims. This scenario could lead to a back-and-forth (or patent prosecution) between your patent attorney and a patent examiner. The typical application takes upward of two to five years from filing to granting, according to Wolin, and extensive patent prosecution will only increase your cost. Once granted, a utility patent expires 20 years from the date of filing.
Before you file a patent application, Wolin advises, it's imperative that you study the marketplace to make sure that your invention does, in fact, represent a new iteration of mousetrap.
"You need to be mindful of what the industry is, how crowded it is, what your innovation is and how impactful it is," Wolin says. "You don't need a patent to sell something. I could put something together in my garage and sell it tomorrow. But if you don't have a patent, somebody else might have a patent. Even if you're not going to focus on intellectual property, you have to make sure you're clear of others' intellectual property."

How to Protect Your Business Idea Without a Patent

It's natural to fear that your idea might be stolen. But you can't turn your vision into reality without the help of others. Sooner or later, you're going to want to ask an industry expert to evaluate your product or service. You're going to need to collaborate with a manufacturer or distributor. But patents cost thousands of dollars and take years to be issued. You can't afford to wait that long to start bringing your product to market.
Thankfully, there are creative ways to actively protect your idea without applying for a patent. Here are four affordable strategies that will protect your business idea from being stolen:
Do your research. Before you begin working with anyone new, be it an individual or organization, do some research online. Do they have a good track record? Can you find any complaints about their business practices? Try to get a sense of what they're all about. If you find cause for concern, consider asking about it. As we all know, not everything you find online is true. But if their business practices seem sketchy before you've even begun to work with them, that's not a good sign.
Use these three legal tools -- with the help and oversight of an attorney:
  • Non-disclosure agreement (NDA): Have anyone you work with sign a non-disclosure agreement that commits them to confidentiality. An NDA can be a mutual agreement between two parties not to share information with third parties, or it can go one-way (since you're sharing information about your idea with them). If the agreement doesn't have an expiration date, that's powerful.
  • Non-compete agreement: If you hire someone to help you, have him or her sign a non-compete agreement. A non-compete agreement prevents an individual or entity from starting a business that would compete or threaten yours within an established radius.
  • Work-for-hire agreement: If you hire someone to help fine-tune your product, make sure to establish that you own any and all improvements made to the idea. Anything they come up with, you own. You will still need to list the person who came up with improvements as a co-inventor in your patent, but they will have no rights to your invention.
Turn to the U.S. Patent and Trademark Office for help. Fortunately, patents aren't the only tools available to protect our ideas. First, file a provisional patent application. You can do this yourself online or use a template such as Invent + Patent System or Patent Wizard to help you. The USPTO also has call centers available with staff members on hand to answer questions and offer guidance.
Filing a PPA costs a little over $100, while patents can easily cost thousands of dollars in legal fees, depending on the complexity of your idea. A provisional patent application protects your idea for up to one year and allows you to label your idea as "patent pending." You can then use the year to gain valuable insight into your idea.
Also, consider applying for a trademark, which you can also easily doonline. This costs several hundred dollars and will help you establish ownership. Because names become synonymous with products, having a registered trademark cements the impression that the idea you're selling is closely associated with your product.
Build relationships with your competitors. This may sound counterintuitive, but establishing mutually beneficial relationships with your greatest competitors is one of the best ways to protect your idea. When I launched my own novelty guitar pick business, I hired the largest producer in the industry to manufacture our picks. They had little motivation to rip me off because they were already profiting from the success of my business. By giving them business, we were not seen as a threat (even though, in reality, we shared the same market space). We respected one another.
These tips will make it harder for others to steal your idea. With any legal document, be sure to consult an attorney to guarantee accuracy and protection of your idea.How to Protect Your Business Idea Without a Patent

quinta-feira, 16 de junho de 2016

How are you doing?

Hey!
Dears readers,

First, I want to apologize to all of you. I was sick and I worked really hard lasts months. Because of these things I just abandoned the blogg. But now I'm coming back again!
If you have any questions to discuss here, you can send me email to your question or news about patent and innovation. My email adress: rezendema@hotmail.com or mayara.inca.cemo@gmail.com.

It was really good to see even I was missed my blogg have been visited. I'm really surprise and I want you thank all of you.

Best regards,

Mayara Rezende
manager

Patents: a question of utility...

Intellectual property

A question of utility

Patents are protected by governments because they are held to promote innovation. But there is plenty of evidence that they do not.


THE Great Exhibition, staged in London in 1851, was intended to show off the inventive genius of Victorian Britain. In doing so it sparked a hardfought debate on intellectual property. On one side were public figures horrified at the thought of inviting the whole world to see the nation’s best ideas, only to have most of it go straight home and copy them. They called for the patent system to be made cheaper and easier to navigate, and for the rights it conferred to be more forcefully upheld. These demands, though, were met with a backlash. Supported by economic liberals who had successfully fought for the repeal of the protectionist Corn Laws a few years earlier, this side of the debate argued that free trade and competition were good for the economy; that patents were a restraint on both; and that therefore patents should be not reformed, but done away with.
The Economist, founded by opponents of the Corn Laws, was an enthusiastic promoter of this abolitionist movement. A leader in our July 26th issue that year thundered that the granting of patents “excites fraud, stimulates men to run after schemes that may enable them to levy a tax on the public, begets disputes and quarrels betwixt inventors, provokes endless lawsuits [and] bestows rewards on the wrong persons.” In perhaps our first reference to what are now called “patent trolls”, we fretted that “Comprehensive patents are taken out by some parties, for the purpose of stopping inventions, or appropriating the fruits of the inventions of others.”
Arguing that patents “rarely give security to really good inventions” and fail at their job of encouraging innovation by rewarding inventors for their efforts, we backed the abolitionists in a debate over patent reforms then in Parliament. Our knockout argument: most of the wonders of the modern age, from mule-spinning to railways, steamships to gas lamps, seemed to have emerged without the help of patents. If the Industrial Revolution didn’t need them, why have them at all?
From Trevithick to trolls
The debate raged on for years and through several changes of government. In 1883, though, Parliament decided that instead of killing patents, it would improve them. The struggle has been taken up again at various times and places. In the first half of the 20th century, for example, many Americans worried that patents were helping corporations such as AT&T monopolise whole industries. In 1938 the Federal Communications Commission urged Franklin Roosevelt to replace them with compulsory licensing. But whenever the issue comes up, lawmakers conclude that the patent system can be perfected and another round of reforms is all that is needed.
During all this time the conceptual and geographical domain of the patent-clerk has expanded. The ability to patent has been extended from physical devices to software and stretches of DNA, not to mention—notably in America—to business processes and financial products. The fear of international competition that came to the fore at the time of the Great Exhibition has seen the system spread around the world, typically as the price that smaller or poorer nations pay for access to the markets of the richer and more lawyered-up. It was this sort of international pressure that brought the Netherlands’ 19th-century experiment with patent abolition to an end. It has been the lure of membership of the World Trade Organisation that has pushed patent rights into emerging economies such as China’s. One of the reasons why talks on the proposed Trans-Pacific Partnership, a trade deal involving countries which produce 40% of the world’s economic output, ended inconclusively last month was the strong patent protection Western countries wanted for biotech-based drugs.
One argument backers like to make is that patents serve the public good. That was not their original purpose. As one of Britain’s 19th-century abolitionists, John Lewis Ricardo, a telegraph entrepreneur and a nephew of David Ricardo, a leading economist, noted in Parliament, sovereigns first introduced them as nice little earners; in the early 17th century King James I was raising £200,000 a year from granting patents. But over time they came to be seen as beneficial to the people as well as to the monarch—a tool with which to “promote the progress of science and useful arts”, as the American constitution puts it.
The public-good position on patents is simple enough: in return for registering and publishing your idea, which must be new, useful and non-obvious, you get a temporary monopoly—nowadays usually 20 years—on using it. This provides an incentive to innovate because it assures the innovator of some material gain if the innovation finds favour. It also provides the tools whereby others can innovate, because the publication of good ideas increases the speed of technological advance as one innovation builds upon another.
This sounds plausible. But is it true? There is much room for doubt. The evidence that the current system encourages companies to invest in research in a way that leads to innovation, increased productivity and general prosperity is surprisingly weak. A growing amount of research in recent years, including a 2004 study by America’s National Academy of Sciences, suggests that, with a few exceptions such as medicines, society as a whole might even be better off with no patents than with the mess that is today’s system.
The post-hoc patent
Michele Boldrin and David Levine, two economists, pulled all this research together in abook published in 2008 and in “The Case Against Patents”, a 2012 paper for the Federal Reserve Bank of St Louis. They argue that patents are neither as good at rewarding innovation nor as helpful in propagating it as claimed.
Take, first, the idea that patents give you a higher rate of innovation. If you look at things such as the number of inventions presented at international fairs, the evidence suggests that 19th-century countries that lacked patent systems were no less innovative than those which had them, though they did innovate in somewhat different areas. Reviewing 23 20th-century studies Mr Boldrin and Mr Levine found “weak or no evidence that strengthening patent regimes increases innovation”—all it does is lead to more patents being filed, which is not the same thing. Several of these studies found that “reforms” aimed at strengthening patent regimes, such as one undertaken in Japan in 1988, for the most part boosted neither innovation nor its supposed cause, R&D spending.
An exception to this general finding reveals another interesting point. A study of Taiwan’s 1986 reforms found that they did lead to more R&D spending in the country and more American patents being granted to Taiwanese people and enterprises. This shows that countries whose patent protection is weaker than others’ can divert investment and R&D spending to their territory by strengthening it. But it does not demonstrate that the overall amount of spending or innovation worldwide has been increased.
If patents encourage worthwhile innovation, then you might expect expansions of the patent system to bring about more of it. Studies from plant breeding suggest this is not so. In 1970 America expanded patent protection to crops that reproduce sexually; subsequent studies on wheat, which is such a crop, showed neither greater research spending nor an increase in the rate at which yields improved. Patent protection on biotech products of all kinds was expanded in the 1980s; as with the change made in 1970, the productivity of American agriculture rose at more or less the same rate after the expansion as before.
When changes in the rate of innovation do occur, they seem to have little to do with patents. Mr Boldrin and Mr Levine observe that in industries from chemicals to carmaking to computer software, waves of innovation began with a surge in inventiveness with lots of participants. Patents only started to be filed years later, once the innovation had died down and the incumbents in the maturing industry were seeking to exclude new entrants, as well as to protect themselves from their rivals’ lawsuits. Patents were a result of successful innovation; its cause was competition.
This is not to say that patents offer no genuine benefits, especially to parties with little access to capital but some ideas. But in many mature, complex manufacturing businesses—aerospace and carmaking, for example—control of the underlying intellectual property is only a small part of what is needed to create and market a world-beating, innovative product. If that were not the case, China’s makers of cars and planes, which have been given a free hand—a helping hand, some competitors say—by their government to pinch Western technology, would be vying with rich-country rivals such as BMW and Boeing. They are not.
In one of the world’s most important businesses, software, there has been something of a backlash against close-held intellectual property. Proprietary software normally does not allow the user access to the source code it depends on; open-source software gives them access to everything as long as any modification they make is made similarly accessible. This can work on a large scale—witness Android, the world’s most successful smartphone operating system.
Pitfalls and piracy
Leaving aside the spurring of innovation, what of the route patents are supposed to provide for its diffusion? That, too, is hard to spot. Mr Boldrin and Mr Levine argue that patent filings tend to be carefully written so as to obscure how the patented idea works even from experts in the field. In his history of intellectual property, “Piracy”, Adrian Johns of the University of Chicago notes that such shenanigans were already under way in the 18th century, with inventors taking care to leave out as much detail as possible from their applications. A counterpart to this defensive ploy is the filing of “submarine” patents: vague and speculative applications made by parties who then try, through various ploys, to keep the application from being granted until other people seem to be making progress on the technology in question. At that point the submarine surfaces with a view to demanding licensing fees.
If patents do not hold many advantages, why do they persist and indeed multiply? In some industries and countries they have become a measure of progress in their own right—a proxy for innovation, rather than a spur. Chinese researchers, under orders to be more inventive, have filed a flurry of patents in recent years (see chart 1). But almost all are being filed only with China’s patent office. If they had real commercial potential, surely they would also have been registered elsewhere, too.
Another reason people might file patents that they don’t need—thus explaining why anything between 40% and 90% of all patents issued are never used or licensed by their owners—is self-defence. In much of the technology industry companies file large numbers of patents (see chart 2), but this is mostly to deter their rivals: if you sue me for infringing one of your thousands of patents, I’ll use one of my stash of patents to sue you back. Such stand-offs make life hard for newcomers: a 2001 study found that fledgling microchip makers were having to spend up to $200m licensing intellectual property that might not be much use to them just to fend off lawsuits. This sort of situation might be good for the incumbents, if not for competition and the public interest; but there is a fair chance it is not good even for them. Some studies have found “thickets” of patents that make it harder for all companies to launch new products.
Even if many industries do not really need patents—and a fair few might be better off without them—there is still a strong belief that in some businesses they are vital. The example always touted is pharmaceuticals. Drugs have to undergo exceptionally expensive and long-drawn-out testing procedures to demonstrate that they are safe and effective. And once a company has laboriously demonstrated that a molecule does its job with few or manageable ill effects, its rivals could make far cheaper copies were it not for patent protection. That is why proponents of patents see it as reasonable to let Bristol-Myers Squibb have a temporary monopoly on Opdivo, its new melanoma drug, and to charge $120,000 per course of treatment in America. If the company could not do so, the argument goes, it would not have spent a fortune on getting the drug and its complex manufacturing process approved.
The Bayer necessities
However, the history of the industry raises doubts about such arguments. Until 1967 German drug companies could only patent the way they made drugs, not the formulae of the drugs themselves. Anyone could sell copies of the medicines if they found another method of making them. Yet Mr Boldrin and Mr Levine say German drugmakers produced more innovations than British ones (remember where aspirin was invented). Another interesting case is Italy, which had no patent protection for drugs until 1978. One study showed it invented a larger proportion of the world’s new medicines before that date than afterwards. Before the “reform” it had lots of copycat firms, but the biggest of these also did research on drugs of their own. They were largely wiped out once they had to pay royalties on their copycat drugs.
It is true that, encouraged by the prospects of patents, pharma companies do a lot more research today than in the 1960s and 1970s. But it is also true that they are not alone in their endeavours. Public support for biomedical research has soared over past decades; the budget of America’s National Institutes of Health is five times what it was in 1970. Mr Boldrin and Mr Levine reckon that once subsidies and tax breaks are accounted for, American private industry pays for only about a third of the country’s biomedical research. In return the patent system provides them with a great deal of income.
The drug companies claim this is a good deal; that the short-term gains a spate of cheap drugs would bring right after a putative abolition would be overshadowed by the long-term losses due to a dearth of new drugs. Looking at one industry-funded studythat reaches this conclusion, though, Mr Boldrin and Mr Levine found it quite sensitive to the discount rate applied to future benefits. In 2005 Dean Baker, an economist at the Centre for Economic and Policy Research, a think-tank in Washington, DC, took a much simpler, but still rather striking, approach: he just compared the costs imposed by the patent system with the innovation that system bought.
America’s health systems, he noted, spent $210 billion on prescription drugs that year. Based on how much cheaper generic drugs were than patented ones, Mr Baker calculated that a competitive patent-free market might have provided the same drugs for no more than $50 billion. That represented a saving of $160 billion.
The drug companies reckoned at the time that they were spending $25 billion on R&D; the government was spending $30 billion on basic medical research. The money it would have been able to save buying drugs for Medicare and Medicaid in a patent-free world have allowed the government to double that research spending, more than replacing industry’s R&D, while still leaving $130 billion in public benefit.
With America’s prescription-drug bill now $374 billion, the opportunity looks all the greater, even though the companies now say they are putting $51 billion a year into R&D. Imagining that the government could spend R&D money as effectively as the corporate sector may sound like a stretch. But a government which simply wanted to make drugs available for competitive manufacture might find various ways to get innovative results from contract research companies. Joseph Stiglitz, an economist at Columbia University, and others have suggested encouraging teams of autonomous scientists to develop new breakthrough drugs by offering those that succeed big prizes.
After a promising drug was found the final, most expensive stages of clinical trials, which measure the efficacy of a drug that has already been shown to be safe, could be publicly funded, using another portion of the huge potential savings from cheaper drugs, and conducted by independent laboratories. Once a medicine was validated, any drug company would be allowed to make it. Alternatively, the trials could be made smaller, with companies required to earn the right to manufacture a drug that had been shown to be safe by scrupulously collecting and publishing data on how the drug compared with other treatments once it was in use.
This is not as strange as it may sound. Many drug startups see their exit strategy as being bought up for a billion dollars or so by a big pharma company when their projects start to look promising. Billion-dollar prizes would provide similar incentives. Nor is it all that new: Robert MacFie, a leading Victorian patent-abolitionist, also favoured prizes.
Six bills to reform patents in some way (including in one case by overturning an earlier reform) have been proposed to the current American Congress. None seeks abolition: any lawmaker brave enough to propose doing away with them altogether, or raising similar questions about the much longer monopolies given to copyright holders, would face an onslaught from the intellectual-property lobby.
But a top-to-bottom re-examination of whether patents and other forms of intellectual-property protection actually do their job, and even whether they deserve to exist, is long overdue. Simple abolition raises problems in terms of the ethics of property rights (see leader). But reductions in the duration of exclusive rights and differentiation between those rights for different sorts of innovation are possible, and could be introduced in steps over a number of years, allowing plenty of time for any ill effects to surface. Experiments with other forms of financing innovation could be run alongside the patent system. If defenders of the patent system really seek to foster innovation, they should be prepared to do so in their own backyard.

CRISPR crunch



Genetic engineering

CRISPR crunch

A row over who invented a new gene-editing technique heats up



“IT HAS not escaped our notice”, wrote James Watson and Francis Crick in 1953, “that the specific pairing we have postulated immediately suggests a possible copying mechanism.” What they had discovered was the structure of DNA and the way its halves matched up. It was a classic of understatement, for what they had noticed would revolutionise biology.
With similar self-restraint, results published in Science, in 2012, noted “considerable potential for gene-targeting and genome-editing applications”. In fact, the study revealed a simple method allowing scientists to tinker, at will, with the genomes of animals and plants. It threw open the doors to a new and egalitarian era of genetic engineering—a way to tackle problems ranging from pest control to drug design to the undoing, with military precision, of harmful mutations. What remains to be determined, however, is who can claim to have discovered it.

The CRISPR-Cas9 approach, as it is known, consists of a protein that can cut DNA and a short string of RNA that identifies where to do the cutting. It won two of the authors of the Science paper—Jennifer Doudna, of the University of California, Berkeley, and Emmanuelle Charpentier, of the Helmholtz Centre for Infection Research, in Germany—a $3m Breakthrough Prize in 2014. This week, Dr Doudna told a packed house at the AAAS meeting how it worked. She recounted how a serendipitous discovery about a bit of biochemistry, borrowed from a bacterium, led her team to a transformative technique that is already being put to use.
In parallel, however, a nasty patent dispute has been unfolding. Although Dr Doudna and her colleagues were the first to file a patent on CRISPR-Cas9, they were not awarded the rights to exploit it commercially. That privilege was granted in 2014 to Feng Zhang, of the Broad Institute and the Massachusetts Institute of Technology (MIT), both in Cambridge, who also claim to have discovered the technique. This decision has been challenged, and in January the United States Patent and Trademark Office (USPTO) said it would begin a process to decide which side could claim ownership.
Cutting questions
The nub of the Broad’s argument is that what Team Doudna did is not gene-editing but rather little more than a study of the properties of a purified protein in a test tube. Robert Desimone, head of the McGovern Institute for Brain Research at MIT, has written that their work “involved no cells, no genomes and no editing”. Team Zhang, by this account, really put CRISPR-Cas9 to work by showing it functioned in mammalian cells. This view was reflected in a hackle-raising paper in January in Cell, by Eric Lander, head of the Broad, outlining a history of gene-editing that elevated the work of Team Zhang while marginalising that of Team Doudna.
Supporters of Dr Doudna and her colleagues argue differently. Although CRISPR-Cas9 is by far the simplest gene-editing technique, it is not the first; others that rely on different nucleases, which do the DNA snipping, have been in use for a number of years. There is a pattern in the development of these other, trickier techniques: the substantive innovation, the one that ultimately leads to a functioning gene-editor, has been the ability to cut DNA at specific locations, something Dr Doudna did in fact show—in a test tube.
The forthcoming USPTO proceedings must therefore determine who knew what and when. Although these days patents are granted on a simpler “first to file” basis, the dispute will be settled under the older, “first to invent” standard, which was in place when both applications were made. The question for the USPTO in its hearings, which start on March 9th, is which party made the discovery in the lab first—something that is as yet not clear.
Team Zhang will be the “junior party” in the dispute, so the burden of proof lies with them. To win, Dr Zhang will need to show that he discovered CRISPR-Cas9 editing long before Dr Doudna’s paper in 2012. The Broad may even use as evidence work that was carried out in test tubes.
None of this seems to have slowed commercial activity surrounding the technique. Editas, a company that currently holds the disputed patent, has said it will go public this year. Firms such as Caribou Biosciences, CRISPR Therapeutics and Intellia Therapeutics are also pursuing commercial applications of the approach; these either hold or license a patent filed by Dr Doudna that is pending. Whoever ultimately lays claim to the power over genomes that CRISPR-Cas9 represents, its “considerable potential” will be realised.
But some things—including more prizes, and possibly a Nobel—do hang in the balance. When Dr Doudna took questions from the press at the AAAS meeting, there was more interest in legal, rather than scientific, issues. Asked how she was dealing with the furore, Dr Doudna said: “Fortunately there are people who are way above my pay grade dealing with that.”

Time to fix Patents


Innovation

Time to fix patents

Ideas fuel the economy. Today’s patent systems are a rotten way of rewarding them


IN 1970 the United States recognised the potential of crop science by broadening the scope of patents in agriculture. Patents are supposed to reward inventiveness, so that should have galvanised progress. Yet, despite providing extra protection, that change and a further broadening of the regime in the 1980s led neither to more private research into wheat nor to an increase in yields. Overall, the productivity of American agriculture continued its gentle upward climb, much as it had before.
In other industries, too, stronger patent systems seem not to lead to more innovation (seearticle). That alone would be disappointing, but the evidence suggests something far worse.



Patents are supposed to spread knowledge, by obliging holders to lay out their innovation for all to see; they often fail, because patent-lawyers are masters of obfuscation. Instead, the system has created a parasitic ecology of trolls and defensive patent-holders, who aim to block innovation, or at least to stand in its way unless they can grab a share of the spoils. An early study found that newcomers to the semiconductor business had to buy licences from incumbents for as much as $200m. Patents should spur bursts of innovation; instead, they are used to lock in incumbents’ advantages.
The patent system is expensive. A decade-old study reckons that in 2005, without the temporary monopoly patents bestow, America might have saved three-quarters of its $210 billion bill for prescription drugs. The expense would be worth it if patents brought innovation and prosperity. They don’t.
Innovation fuels the abundance of modern life. From Google’s algorithms to a new treatment for cystic fibrosis, it underpins the knowledge in the “knowledge economy”. The cost of the innovation that never takes place because of the flawed patent system is incalculable. Patent protection is spreading, through deals such as the planned Trans-Pacific Partnership, which promises to cover one-third of world trade. The aim should be to fix the system, not make it more pervasive.
The English patent
One radical answer would be to abolish patents altogether—indeed, in 19th-century Britain, that was this newspaper’s preference. But abolition flies in the face of the intuition that if you create a drug or invent a machine, you have a claim on your work just as you would if you had built a house. Should someone move into your living room uninvited, you would feel justifiably aggrieved. So do those who have their ideas stolen.
Yet no property rights are absolute. When the benefits are large enough, governments routinely override them—by seizing money through taxation, demolishing houses to make way for roads and controlling what you can do with your land. Striking the balance between the claim of the individual and the interests of society is hard. But with ideas, the argument that the government should force the owners of intellectual property to share is especially strong.
One reason is that sharing ideas will not cause as much harm to the property owner as sharing physical property does. Two farmers cannot harvest the same crops, but an imitator can reproduce an idea without depriving its owner of the original. The other reason is that sharing brings huge benefits to society. These spring partly from the wider use of the idea itself. If only a few can afford a treatment, the diseased will suffer, despite the trivially small cost of actually manufacturing the pills to cure them. Sharing also leads to extra innovation. Ideas overlap. Inventions depend on earlier creative advances. There would be no jazz without blues; no iPhone without touchscreens. The signs are that innovation today is less about entirely novel breakthroughs, and more about the clever combination and extension of existing ideas.
Governments have long recognised that these arguments justify limits on patents. Still, despite repeated attempts to reform it, the system fails. Can it be made to work better?
Light-bulb moment
Reformers should be guided by an awareness of their own limitations. Because ideas are intangible and innovation is complex, Solomon himself would find it hard to adjudicate between competing claims. Under-resourced patent-officers will always struggle against well-heeled patent-lawyers. Over the years, the regime is likely to fall victim to lobbying and special pleading. Hence a clear, rough-and-ready patent system is better than an elegant but complex one. In government as in invention, simplicity is a strength.
One aim should be to rout the trolls and the blockers. Studies have found that 40-90% of patents are never exploited or licensed out by their owners. Patents should come with a blunt “use it or lose it” rule, so that they expire if the invention is not brought to market. Patents should also be easier to challenge without the expense of a full-blown court case. The burden of proof for overturning a patent in court should be lowered.
Patents should reward those who work hard on big, fresh ideas, rather than those who file the paperwork on a tiddler. The requirement for ideas to be “non-obvious” must be strengthened. Apple should not be granted patents on rectangular tablets with rounded corners; Twitter does not deserve a patent on its pull-to-refresh feed.
Patents also last too long. Protection for 20 years might make sense in the pharmaceutical industry, because to test a drug and bring it to market can take more than a decade. But in industries like information technology, the time from brain wave to production line, or line of code, is much shorter. When patents lag behind the pace of innovation, firms end up with monopolies on the building-blocks of an industry. Google, for instance, has a patent from 1998 on ranking websites in search results by the number of other sites linking to them. Here some additional complexity is inevitable: in fast-moving industries, governments should gradually reduce the length of patents. Even pharmaceutical firms could live with shorter patents if the regulatory regime allowed them to bring treatments to market sooner and for less upfront cost.
Today’s patent regime operates in the name of progress. Instead, it sets innovation back. Time to fix it.

PATENTES E SAÚDE PÚBLICA SÃO TEMAS DE DEBATE NA FIOCRUZ

Patentes e saúde pública são temas de debate na Fiocruz (12/04/2016)


Reinaldo Guimarães diz que o esvaziamento de organismos internacionais como a OMS favorece os países mais desenvolvidos - Foto: Peter Ilicciev
A precariedade do sistema de patentes no Brasil e as contradições entre os interesses comerciais e o direito à saúde em todo o mundo foram temas do seminário apresentado pelo médico e segundo vice-presidente da Associação Brasileira da Indústria de Química Fina, Biotecnologia e suas Especialidades (Abifina), Reinaldo Guimarães. Realizado na quinta-feira (7/4), no auditório da Escola Nacional de Saúde Pública (Ensp/Fiocruz), em Manguinhos, no Rio de Janeiro, o evento foi uma iniciativa do Centro de Desenvolvimento Tecnológico em Saúde (CDTS/Fiocruz).
Com longo histórico de contribuições para a saúde pública no Brasil, Reinaldo Guimarães iniciou sua apresentação afirmando que a propriedade intelectual é a política pública mais negligenciada do país. De acordo com o diretor da Abifina, os produtos de saúde, também conhecidos como tecnologia médica, são um dos cinco maiores campos em termos de depósito de patente no mundo. Apesar disso, o sistema geral de patentes no Brasil, tanto em suas instâncias formuladora, normativa e executora, vive uma grave crise.
“O Instituto Nacional da Propriedade Industrial (INPI) tem hoje mais de 184 mil pedidos de patentes depositadas e não examinadas. O tempo médio para a concessão de patente pelo INPI na área de fármacos é de 12 anos. É como se não existisse”, enfatizou Reinaldo Guimarães. “A lei de patentes brasileira diz que o produto tem mais dez anos de proteção patentária depois do exame do INPI. Isso cria uma proteção muito maior do que os 20 anos utilizados em todo o mundo. A extensão da vigência das patentes gera prejuízo aos cofres públicos”, explicou.
Analisando o contexto mundial, dos últimos vinte e cinco anos, o diretor da Abifina e ex-presidente de Pesquisa e Desenvolvimento Tecnológico da Fiocruz declarou que o esvaziamento dos organismos internacionais, como a Organização Mundial de Saúde (OMS), acentua as contradições entre os interesses comerciais e o direito à saúde. Reinaldo Guimarães disse que o campo da saúde pública traz muitas especificidades, já que diz respeito ao direito à vida. “Você pode viver sem um smartphone, mas não pode viver sem acesso aos remédios que precisa. O maior desafio hoje é como conciliar o interesse comercial, a inovação e o desenvolvimento de novos produtos com o interesse público”, complementou.
Neste cenário, Reinaldo Guimarães propõe uma agenda de resistência, frente à perda do protagonismo da OMS e à crescente pressão por acordos bilaterais sobre propriedade intelectual. Como as leis de patentes fazem parte de uma política de Estado, as chamadas “harmonizações” em pauta nestas negociações favorecem as nações mais ricas do planeta e sempre envolvem a perda da soberania nacional dos países em desenvolvimento.
“Para um país assinar um acordo de livre comércio, este tem que se adequar às normas de propriedade intelectual do polo mais forte do acordo. É uma harmonização nesse sentido. Por isso, os Estados Nacionais têm que ter uma posição mais soberana na definição de suas políticas e a indústria precisa compreender que a ampliação do acesso aos medicamentos é uma obrigação moral e compatível com o desenvolvimento industrial e a geração de receitas”, disse.